Wolgast M, Larson M, Nygren K
Am J Physiol. 1981 Aug;241(2):F105-11. doi: 10.1152/ajprenal.1981.241.2.F105.
The renal interstitial space analyzed as "inulin space" comprises about 13% in the rat. The Starling forces of this compartment are governed by the balance between tubular and capillary fluid transport and also by the leakage of plasma proteins from the blood side. Protein transport will occur in a large-pore system in the peritubular capillary membrane. During control antidiuresis, the interstitial hydrostatic pressure is 2-4 mmHg. The colloid osmotic pressure shows a larger variability but is generally about 5 mmHg. During conditions of depressed capillary reabsorption but unchanged tubular reabsorption, as in saline expansion, the interstitial hydrostatic pressure rises 3-4 times, whereas the colloid osmotic pressure will show a steep fall resulting from the increased fluid entry and unchanged protein transport. The interstitial volume increases only slightly, since it is compressed by the expanding tubules. The influence of interstitial physical forces on tubular transport remains unclear, mainly due to the inaccessibility of the lateral interspaces to direct measurement of relevant parameters.
以“菊粉空间”分析的肾间质约占大鼠总体积的13%。该腔室的Starling力由肾小管和毛细血管液体转运之间的平衡以及血浆蛋白从血液侧的渗漏所决定。蛋白质转运将发生在肾小管周围毛细血管膜的大孔系统中。在对照性抗利尿期间，间质静水压为2 - 4 mmHg。胶体渗透压变化较大，但通常约为5 mmHg。在毛细血管重吸收降低但肾小管重吸收不变的情况下，如在盐水扩容时，间质静水压升高3 - 4倍，而胶体渗透压将因液体进入增加和蛋白质转运不变而急剧下降。间质体积仅略有增加，因为它被扩张的肾小管压缩。间质物理力对肾小管转运的影响仍不清楚，主要是由于侧向间隙难以直接测量相关参数。
