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混合性神经肌肉阻滞:预箭毒化的作用

Mixed neuromuscular block: the effect of precurarization.

作者信息

Ferguson A, Bevan D R

出版信息

Anaesthesia. 1981 Jul;36(7):661-6. doi: 10.1111/j.1365-2044.1981.tb08776.x.

DOI:10.1111/j.1365-2044.1981.tb08776.x
PMID:7270841
Abstract

The effects of precurarisation, with small doses of pancuronium, curare or gallamine, on the neuromuscular blockade following suxamethonium, 1 mg/kg, were studied using train-of-four stimulation. The duration of the block was reduced by pretreatment with d-tubocurarine and gallamine but increased with pancuronium. The degree of competitive neuromuscular blockade, both after administration of the precurarising dose and at full recovery from suxamethonium was mild and was insufficient to be a cause of postoperative muscle weakness.

摘要

使用四个成串刺激法研究了小剂量潘库溴铵、筒箭毒碱或加拉明预箭毒化对1mg/kg琥珀胆碱所致神经肌肉阻滞的影响。用d-筒箭毒碱和加拉明预处理可缩短阻滞持续时间,但用潘库溴铵预处理则会延长阻滞持续时间。预箭毒化剂量给药后及琥珀胆碱完全恢复时的竞争性神经肌肉阻滞程度均较轻,不足以成为术后肌肉无力的原因。

相似文献

1
Mixed neuromuscular block: the effect of precurarization.混合性神经肌肉阻滞:预箭毒化的作用
Anaesthesia. 1981 Jul;36(7):661-6. doi: 10.1111/j.1365-2044.1981.tb08776.x.
2
Effect of prior administration of a non-depolarising muscle relaxant on the action of suxamethonium in the dog.预先给予非去极化肌松药对狗琥珀胆碱作用的影响。
Res Vet Sci. 1984 May;36(3):348-53.
3
Five non-depolarizing muscle relaxants in precurarization.
Acta Anaesthesiol Scand. 1983 Dec;27(6):427-32. doi: 10.1111/j.1399-6576.1983.tb01981.x.
4
Nitroglycerin and the neuromuscular blockade produced by gallamine, succinylcholine, d-tubocurarine, and pancuronium.硝酸甘油与加拉明、琥珀酰胆碱、d -筒箭毒碱和泮库溴铵产生的神经肌肉阻滞作用。
Anesth Analg. 1980 Feb;59(2):117-22.
5
Inhibition of suxamethonium relaxation by tubocurarine and gallamine pretreatment during induction of anaesthesia in man.
Br J Anaesth. 1975 Oct;47(10):1067-73. doi: 10.1093/bja/47.10.1067.
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Relative potency of some neuromuscular blocking drugs in vivo and in vitro.一些神经肌肉阻滞药物在体内和体外的相对效价。
Med Biol. 1978 Jun;56(3):152-5.
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Effect of prior administration of suxamethonium on non-depolarising muscle relaxants in the dog.琥珀胆碱预先给药对犬非去极化肌松药的影响。
Res Vet Sci. 1984 Jan;36(1):43-7.
8
Cardiovascular effects of muscle relaxants.肌肉松弛剂对心血管系统的影响。
AANA J. 1981 Feb;49(1):35-42.
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Influence of gallamine, pancuronium, d-tubocurarine and succinylcholine on adrenergic neurotransmission.加拉明、泮库溴铵、d-筒箭毒碱和琥珀酰胆碱对肾上腺素能神经传递的影响。
Acta Anaesthesiol Belg. 1979;30 Suppl:71-8.
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Monitoring of neuromuscular function.神经肌肉功能监测。
Anesthesiology. 1976 Aug;45(2):216-49. doi: 10.1097/00000542-197608000-00009.

引用本文的文献

1
In vitro potency and mode of action of ANQ9040: a novel fast acting muscle relaxant.新型速效肌肉松弛剂ANQ9040的体外效力及作用方式
Br J Pharmacol. 1994 Oct;113(2):642-8. doi: 10.1111/j.1476-5381.1994.tb17038.x.
2
Neuromuscular blocking drugs.神经肌肉阻滞剂
Can Anaesth Soc J. 1983 May;30(3 Pt 2):S56-61. doi: 10.1007/BF03009981.
3
Onset of action of relaxants.松弛剂的起效时间。
Can J Anaesth. 1988 May;35(3 ( Pt 2)):S52-8. doi: 10.1007/BF03026928.
4
Accelerated onset of pancuronium with divided doses.泮库溴铵分剂量给药时起效加速。
Can Anaesth Soc J. 1985 Jan;32(1):1-4. doi: 10.1007/BF03008530.
5
A defasciculating dose of d-tubocurarine causes resistance to succinylcholine.一定剂量的去极化型筒箭毒碱会导致对琥珀酰胆碱产生抗性。
Can J Anaesth. 1990 Jul;37(5):538-42. doi: 10.1007/BF03006322.
6
The use of muscle relaxants in the intensive care unit.重症监护病房中肌肉松弛剂的使用。
Can J Anaesth. 1992 Nov;39(9):949-62. doi: 10.1007/BF03008345.