Doherty W G, Breen P J, Donati F, Bevan D R
Can Anaesth Soc J. 1985 Jan;32(1):1-4. doi: 10.1007/BF03008530.
To determine the consequences of administering neuromuscular relaxants in divided doses, pancuronium was given either in a single dose, 0.07 mg X kg-1, or in an initial dose of 0.007 mg X kg-1 followed three minutes later with 0.063 mg X kg-1. When the drug was administered in divided dosage the onset time was reduced, the block was more intense and its duration of action was prolonged. It is suggested that such changes may be advantageous in the provision of rapid intense paralysis.
为了确定分次给予神经肌肉阻滞剂的后果，将泮库溴铵以0.07mg/kg的单次剂量给药，或以0.007mg/kg的初始剂量给药，三分钟后再给予0.063mg/kg。当药物分次给药时，起效时间缩短，阻滞作用更强，作用持续时间延长。有人认为，这些变化可能有利于提供快速强效的麻痹效果。
