Lescanic M L, Miller E D, DiFazio C A
Anesthesiology. 1981 Sep;55(3):269-72. doi: 10.1097/00000542-198109000-00014.
Radioactively labeled 15-micrometer microspheres were used to evaluate the effects of intravenous lidocaine on cardiac output and distribution of tissue blood flow in awake rats. After a one-hour control period, all animals (n = 22) received 85Sr-labeled microspheres for a control measurement. The animals were then divided into three groups. The control group (n = 6) received a bolus of saline and then an infusion of saline. After 40 minutes, a second microsphere (141Ce) was injected, the animals killed, and tissue blood flow determined. A second group of rats (n = 8) were similarly treated except that they received a bolus and infusion of lidocaine resulting in a plasma concentration of 1.98 +/- 0.3 microgram of lidocaine/ml. A third group of rats (n = 8) received a higher dose of lidocaine which resulted in a plasma concentration of 6.37 +/- 0.3 microgram of lidocaine/ml. In the control and low-dose lidocaine group, there were no changes in blood pressure, heart rate, cardiac output or tissue blood flow. At the higher lidocaine concentration, blood pressure remained the same but cardiac output and heart rate were decreased. Tissue blood flow to brain, heart and muscle was responsible for the increased peripheral resistance. These results suggest that high blood concentrations of lidocaine alter flow to vital organs in the rat.
放射性标记的15微米微球被用于评估静脉注射利多卡因对清醒大鼠心输出量和组织血流分布的影响。在1小时的对照期后，所有动物（n = 22）接受85Sr标记的微球进行对照测量。然后将动物分为三组。对照组（n = 6）接受一次生理盐水推注，然后持续输注生理盐水。40分钟后，注射第二个微球（141Ce），处死动物，并测定组织血流。第二组大鼠（n = 8）接受类似处理，只是它们接受了一次利多卡因推注和输注，使血浆利多卡因浓度达到1.98±0.3微克/毫升。第三组大鼠（n = 8）接受更高剂量的利多卡因，使血浆利多卡因浓度达到6.37±0.3微克/毫升。在对照组和低剂量利多卡因组中，血压、心率、心输出量或组织血流均无变化。在较高的利多卡因浓度下，血压保持不变，但心输出量和心率降低。流向脑、心脏和肌肉的组织血流导致外周阻力增加。这些结果表明，高血药浓度的利多卡因会改变大鼠重要器官的血流。
