Wiklund L
Acta Anaesthesiol Scand. 1977;21(2):148-60. doi: 10.1111/j.1399-6576.1977.tb01204.x.
Twelve healthy young volunteers were studied before and during intravenous administration of lidocaine at a dose rate of 2 or 4 mg/min. Five additional volunteers, who did not receive lidocaine solution but were given the same amount of physiological saline, were studied in the same manner. Heart rate, cardiac output, mean arterial blood pressure, mean right atrial blood pressure, estimated hepatic blood flow and plasma concentration of lidocaine were measured repeatedly. The results showed an increase in heart rate, cardiac output and mean arterial blood pressure, the latter two variables in relation to the plasma concentration of lidocaine. The estimated hepatic blood flow increased, partly as a result of the reduction of splanchnic vascular resistance and partly due to the stimulation of cardiac output. The decrease in splanchnic vascular resistance was proportional to the plasma concentration of lidocaine.
12名健康年轻志愿者在以2或4毫克/分钟的速率静脉注射利多卡因之前和期间接受了研究。另外5名志愿者未接受利多卡因溶液，但给予了相同量的生理盐水，以相同方式进行研究。重复测量心率、心输出量、平均动脉血压、平均右心房血压、估计肝血流量和利多卡因血浆浓度。结果显示心率、心输出量和平均动脉血压增加，后两个变量与利多卡因血浆浓度有关。估计肝血流量增加，部分是由于内脏血管阻力降低，部分是由于心输出量的刺激。内脏血管阻力的降低与利多卡因血浆浓度成正比。
