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Pharmacokinetics of oxfendazole in sheep.

作者信息

Marriner S E, Bogan J A

出版信息

Am J Vet Res. 1981 Jul;42(7):1143-5.

PMID:7271032
Abstract

Pharmacokinetics of oxfendazole and its sulfone metabolite were determined in 6 sheep. Oxfendazole achieved mean peak plasma concentrations of 0.76 micrograms/ml at 30 hours after oral administration of oxfendazole (10 mg/kg of body weight), and concentrations were detectable for up to 7 days after administration. Mean peak abomasal concentrations of 3.55 micrograms/ml occurred 20 hours after administration and were detectable up to 9 days after administration. Concentrations of sulfone in plasma and abomasal fluid were generally lower than were those of oxfendazole.

摘要

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