Suzuki T, Karaki H, Urakawa N
Arch Int Pharmacodyn Ther. 1981 Apr;250(2):195-203.
Rabbit aortic smooth muscle developed a contraction in a solution in which a part or all Na was replaced by equimolar K. Substitution of 80 mM NaCl with KCl produced a sustained contraction while the developed tension gradually declined in the solutions in which more than 120 mM NaCl was replaced by KCl. The decrease in the sustained tension was accompanied by an increase in tissue wet weight and both of the changes were prevented by a hyperosmotic addition of sucrose. Substitution for NaCl with K-propionate did not inhibit the sustained tension nor increased the wet weight of the tissue while substitution with KNO3 or KI produced a greater inhibition of the contraction than with KCl. It is suggested that the swelling of the rabbit aortic smooth muscle cells induced by the substituted KCl solution inhibits the contractility of the muscle.
兔主动脉平滑肌在部分或全部Na被等摩尔K替代的溶液中会发生收缩。用KCl替代80 mM NaCl会产生持续收缩，而在超过120 mM NaCl被KCl替代的溶液中，所产生的张力会逐渐下降。持续张力的降低伴随着组织湿重的增加，而这两种变化都可通过高渗添加蔗糖来阻止。用丙酸钾替代NaCl既不抑制持续张力，也不增加组织的湿重，而用硝酸钾或碘化钾替代则比用KCl对收缩的抑制作用更大。这表明，由替代的KCl溶液诱导的兔主动脉平滑肌细胞肿胀会抑制肌肉的收缩能力。
