蝾螺毒素对猫腹腔神经节的作用（作者译）

[Effect of surugatoxin on celiac ganglia in cats (author's transl)].

作者信息

Hayashi E, Yamada S, Kato M

出版信息

Nihon Yakurigaku Zasshi. 1977 Sep;73(6):657-63. doi: 10.1254/fpj.73.657.

DOI:10.1254/fpj.73.657

Abstract

Pharmacological properties of surugatoxin (SGTX), the toxic principle from Japanese ivory mollusc (Babylonia japonica), have been studied. In the present paper, the effect of SGTX on celiac ganglia in cats was investigated by measuring blood pressure from femoral artery and regional blood flow in liver (LBF) and spleen (SBF) of anaesthetized cats. SGTX(50 nmol/kg i.v.) markedly inhibited both the hypertension and changes of LBF and SBF in response to splanchnic (preganglionic) nerve stimulation. On the other hand, it did not inhibit the changes of SBF by splenic(postganglionic) nerve stimulation. The hypertension and changes in LBF and SBF in response to DMPP(94.2 nmol/kg i.v.) were abolished by SGTX(50 nmol/kg i.v.), whereas those to McN-A-343 (94.8 nmol/kg i.v.) were not. SGTX usually enhanced the pressor response to McN-A-343. These results indicate that SGTX has a blocking effect on the nicotinic receptor in celiac ganglia as well as in superior cervical ganglia of cats and rats.

摘要

对日本象牙贝（日本宝螺）的毒素——蝾螺毒素（SGTX）的药理特性进行了研究。在本文中，通过测量麻醉猫股动脉血压以及肝脏局部血流量（LBF）和脾脏血流量（SBF），研究了SGTX对猫腹腔神经节的影响。静脉注射SGTX（50 nmol/kg）显著抑制了因内脏（节前）神经刺激引起的高血压以及LBF和SBF的变化。另一方面，它并未抑制脾脏（节后）神经刺激引起的SBF变化。静脉注射SGTX（50 nmol/kg）可消除静脉注射DMPP（94.2 nmol/kg）引起的高血压以及LBF和SBF变化，而对静脉注射McN - A - 343（94.8 nmol/kg）引起的变化则无此作用。SGTX通常会增强对McN - A - 343的升压反应。这些结果表明，SGTX对猫和大鼠腹腔神经节以及颈上神经节中的烟碱样受体具有阻断作用。