Cotton B R, Smith G
Br J Anaesth. 1981 Aug;53(8):869-74. doi: 10.1093/bja/53.8.869.
The effects of atropine and metoclopramide on the lower oesophageal sphincter pressure (LOSP) were studied in 12 healthy volunteers using oesophageal pressure transducers. Atropine decreased LOSP significantly at 5 min after i.v. injection (P less than 0.005) and this change was sustained for 60 min. Metoclopramide increased LOSP significantly at 3 min after administration i.v. (P less than 0.05) and this change was sustained for 40 min. Following consecutive administration of the drugs the effects of atropine predominated.
使用食管压力传感器，在12名健康志愿者中研究了阿托品和甲氧氯普胺对食管下括约肌压力（LOSP）的影响。静脉注射后5分钟，阿托品使LOSP显著降低（P<0.005），且这种变化持续了60分钟。静脉给药后3分钟，甲氧氯普胺使LOSP显著升高（P<0.05），且这种变化持续了40分钟。连续给药后，阿托品的作用占主导。
