阿托品与格隆溴铵对食管下括约肌压力影响的比较。

Comparison of the effects of atropine and glycopyrrolate on lower oesophageal sphincter pressure.

作者信息

Cotton B R, Smith G

出版信息

Br J Anaesth. 1981 Aug;53(8):875-9. doi: 10.1093/bja/53.8.875.

DOI:10.1093/bja/53.8.875

Abstract

Lower oesophageal sphincter pressure (LOSP) has been measured on three separate occasions in nine healthy volunteers using oesophageal pressure transducers. Atropine 0.6 mg decreased LOSP significantly at 5 min after i.v. injection (P less than 0.025) and this change was sustained for 40 min. Glycopyrrolate 0.3 mg or 0.2 mg decreased LOSP significantly at 3 min after i.v. injection (P less than 0.0025). This change was sustained for 60 min and was similar for both doses and also similar in magnitude to the change produced by atropine.

摘要

使用食管压力传感器在9名健康志愿者身上分三次测量了下食管括约肌压力（LOSP）。静脉注射0.6毫克阿托品后5分钟，LOSP显著降低（P<0.025），且这种变化持续了40分钟。静脉注射0.3毫克或0.2毫克格隆溴铵后3分钟，LOSP显著降低（P<0.0025）。这种变化持续了60分钟，两种剂量的效果相似，且在幅度上与阿托品产生的变化相似。