曲唑酮——一种新的测定方法及一些药代动力学参数。
Trazodone--a new assay procedure and some pharmacokinetic parameters.
作者信息
Ankier S I, Martin B K, Rogers M S, Carpenter P K, Graham C
出版信息
Br J Clin Pharmacol. 1981 May;11(5):505-9. doi: 10.1111/j.1365-2125.1981.tb01157.x.
Abstract
1 A simple and specific procedure is described for the determination of the new anti-depressant trazodone in human plasma utilising reverse-phase HPLC which is sensitive to 20 ng ml-1. 2 Following oral administration of single 50 mg doses of two formulations of trazodone on separate occasions to healthy fasted volunteers, the peak plasma concentration, time to peak concentration, area under the curve, elimination rate constant and half-life were determined. 3 The two formulations are closely similar and they are considered to have comparable bioavailability.
摘要
- 描述了一种简单且特异的方法，用于利用对20 ng/ml敏感的反相高效液相色谱法测定人血浆中的新型抗抑郁药曲唑酮。2. 在不同时间分别给健康空腹志愿者口服单剂量50 mg的两种曲唑酮制剂后，测定了血浆峰浓度、达峰时间、曲线下面积、消除速率常数和半衰期。3. 这两种制剂非常相似，被认为具有相当的生物利用度。
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本文引用的文献
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Pharmacological properties of AF 1161, a new psychotropic drug.新型精神药物AF 1161的药理学特性
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Systematic clinical studies with trazodone: methodological aspects.曲唑酮的系统临床研究：方法学方面。
Curr Ther Res Clin Exp. 1973 Oct;15(10):764-8.
6
Clinical experience with a new psychotropic drug, trazodone: a review of literature.新型精神药物曲唑酮的临床经验：文献综述
Curr Ther Res Clin Exp. 1973 Oct;15(10):755-63.
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Pharmacology of trazodone.曲唑酮的药理学
Curr Ther Res Clin Exp. 1973 Oct;15(10):749-54.
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Chemistry of trazodone.
Curr Ther Res Clin Exp. 1973 Oct;15(10):745-8.
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A single dose study of trazodone with an assessment of its effect on mood and arousal.曲唑酮单次给药研究及其对情绪和觉醒影响的评估。
Br J Clin Pharmacol. 1975 Feb;2(1):19-24. doi: 10.1111/j.1365-2125.1975.tb00466.x.
10
[Pharmacokinetics and metabolism of trazodone in man (author's transl)].曲唑酮在人体中的药代动力学与代谢（作者译）
Arzneimittelforschung. 1976;26(11):2084-9.
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