Anderson W H, Archuleta M M
J Anal Toxicol. 1984 Sep-Oct;8(5):217-9. doi: 10.1093/jat/8.5.217.
A simple and specific method is presented for the capillary gas chromatographic determination of trazodone in postmortem blood and tissues. The drug and trimethobenzamide, which was used as an internal standard, were extracted with 1% isopropanol in n-butyl chloride. Chromatography was accomplished with a short (4-m) methyl silicone capillary column and hydrogen carrier gas. This combination of extraction solvent and chromatographic conditions was demonstrated to be both accurate and precise. Since trazodone is a relatively new drug, additional thin layer and packed column gas chromatographic data is presented to augment the incorporation of trazodone into routine analytical protocols.
本文介绍了一种简单而特异的方法，用于毛细管气相色谱法测定死后血液和组织中的曲唑酮。以1%异丙醇的正丁基氯溶液提取药物及用作内标的三甲苯甲酰胺。采用短（4米）甲基硅氧烷毛细管柱和氢气作载气进行色谱分析。结果表明，这种萃取溶剂和色谱条件的组合既准确又精密。由于曲唑酮是一种相对较新的药物，本文还提供了额外的薄层色谱和填充柱气相色谱数据，以促进将曲唑酮纳入常规分析方案。
