Kosenko E A
Biokhimiia. 1981 Aug;46(8):1389-95.
The steady state concentration of carbohydrate and adenosine phosphate metabolites in rat and rabbit liver and in rabbit skeletal muscle and oxidative phosphorylation parameters of rat and rabbit liver mitochondria were compared. The effects of 24 hr starvation on the energy metabolism of liver and skeletal muscle of the animals were investigated. The steady state concentrations of glycogen and phosphoenolpyruvate in normal rabbit liver were found to be much lower than in the rat and other mammalian livers (45.7 mumoles of glucose equivalents and 38 nmoles of PEP per 1 g of liver wet mass, respectively). On the contrast, the concentrations of glucose 6-phosphate, pyruvate and Pi in rabbit skeletal muscle were unusually high (up to 3, 1 and 15 mumoles per 1 g, respectively). In terms of glucose, pyruvate, lactate, Pi, adenine nucleotide contents and cytosolic NAD+/NADH ratio in the liver, and glycogen, glucose, lactate, creatine and adenosine phosphates in skeletal muscle and oxidative and phosphorylated properties of isolated liver mitochondria, no significant differences between rat and rabbit were found. During 24 hr starvation gluconeogenesis in rabbit liver occurred earlier and was more intensive than in rat liver. This is indicative of the existence of interspecies differences in the control mechanisms of carbohydrate and phosphorus metabolism.
比较了大鼠和兔肝脏、兔骨骼肌中碳水化合物和腺苷磷酸代谢物的稳态浓度，以及大鼠和兔肝脏线粒体的氧化磷酸化参数。研究了24小时饥饿对动物肝脏和骨骼肌能量代谢的影响。发现正常兔肝脏中糖原和磷酸烯醇丙酮酸的稳态浓度远低于大鼠和其他哺乳动物肝脏（每1克肝脏湿重分别为45.7微摩尔葡萄糖当量和38纳摩尔磷酸烯醇丙酮酸）。相反，兔骨骼肌中6-磷酸葡萄糖、丙酮酸和无机磷的浓度异常高（每1克分别高达3、1和15微摩尔）。就肝脏中的葡萄糖、丙酮酸、乳酸、无机磷、腺嘌呤核苷酸含量和胞质NAD⁺/NADH比值，以及骨骼肌中的糖原、葡萄糖、乳酸、肌酸和腺苷磷酸，以及分离的肝脏线粒体的氧化和磷酸化特性而言，大鼠和兔之间未发现显著差异。在24小时饥饿期间，兔肝脏中的糖异生比大鼠肝脏更早发生且更强烈。这表明碳水化合物和磷代谢的控制机制存在种间差异。
