Turner W J, King S
Biol Psychiatry. 1981 May;16(5):417-39.
In five pedigrees in which bipolar affective illness (BPD) can be traced through three generations with no father-son transmission, no linkage to HLA could be established. This group was evidently dependent on a single dominant gene (X-linked?), for which the noncommittal designation BPD1 was proposed. Two pedigrees of BPD, in which father-son transmission occurred at least twice, showed highly suggestive linkage to HLA (lod = 2.61 at theta = 0.15). BPD2 was proposed as the designation for this gene. Loss of BPD in one HLA-A/B cross-over suggests that a single dominant gene in this group has a locus in p2-pter region of chromosome 6.
在5个双相情感障碍（BPD）可追溯三代且无父子遗传的家系中，未发现与HLA的连锁关系。该组显然依赖于一个单一显性基因（X连锁？），为此提出了不确定的命名BPD1。在至少发生两次父子遗传的两个BPD家系中，显示出与HLA有高度提示性的连锁关系（在θ=0.15时，lod=2.61）。为此基因提出了命名BPD2。在一次HLA - A/B交换中BPD的缺失表明，该组中的一个单一显性基因在6号染色体的p2 - pter区域有一个基因座。
