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小鼠中阿片类药物散瞳作用的拮抗作用。

Antagonism of opiate mydriasis in mice.

作者信息

Korczyn A D, Rock M

出版信息

Br J Pharmacol. 1981 Aug;73(4):807-10. doi: 10.1111/j.1476-5381.1981.tb08732.x.

DOI:10.1111/j.1476-5381.1981.tb08732.x
PMID:7272583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071488/
Abstract

1 Morphine-induced mydriasis in mice is antagonized by nalorphine, levallorphan and naloxone in a dose-dependent manner. 2 The relative potency of the three agents is 10:56: 134 respectively, thus being in accordance with other tests of narcotic antagonism. Naloxone has the shortest duration of action. 3 When injected into naive animals, nalorphine (but not levallorphan or naloxone) produces a slight mydriasis. 4 Measurement of the diameter of the pupil in mice seems to be a precise, simple and rapid test for studying narcotic antagonist as well as agonist action and has several advantages over standard methods used for this purpose.

摘要

1 纳洛芬、左洛啡烷和纳洛酮能以剂量依赖方式拮抗吗啡引起的小鼠瞳孔散大。2 这三种药物的相对效价分别为10:56:134，因此与其他麻醉拮抗试验结果一致。纳洛酮的作用持续时间最短。3 当注射到未用过药的动物体内时，纳洛芬（而非左洛啡烷或纳洛酮）会引起轻微瞳孔散大。4 测量小鼠瞳孔直径似乎是一种精确、简单且快速的试验，可用于研究麻醉拮抗剂以及激动剂的作用，与用于此目的的标准方法相比有几个优点。

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Antagonism of opiate mydriasis in mice.小鼠中阿片类药物散瞳作用的拮抗作用。
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本文引用的文献

1
N-Allylnoroxy-morphone: a new potent narcotic antagonist.N-烯丙基去氧吗啡：一种新型强效麻醉拮抗剂。
Am J Med Sci. 1963 Jan;245:23-30.
2
Mydriatic activity of analgesics in mice.镇痛药对小鼠的散瞳作用。
Experientia. 1956 Aug 15;12(8):293-4. doi: 10.1007/BF02159614.
3
Tolerance to the Mydriatic effects of morphine in mice.小鼠对吗啡散瞳作用的耐受性。
J Neural Transm. 1980;48(1):43-7. doi: 10.1007/BF01670032.
4
The human pharmacology and abuse potential of N-allylnoroxymorphone (naloxone).N-烯丙基去甲羟吗啡酮（纳洛酮）的人体药理学及滥用可能性
J Pharmacol Exp Ther. 1967 Aug;157(2):420-6.
5
Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone).麻醉性激动剂和拮抗剂的动力学参数，尤其涉及N-烯丙基去甲羟吗啡酮（纳洛酮）。
Br J Pharmacol Chemother. 1968 Jun;33(2):266-76. doi: 10.1111/j.1476-5381.1968.tb00988.x.
6
Naloxone, naltrexone, and related noroxymorphones.
Adv Biochem Psychopharmacol. 1973;8(0):33-43.
7
Effects of opiates and opiate antagonists on the Straub tail reaction in mice.阿片类药物和阿片类拮抗剂对小鼠斯特劳布尾反应的影响。
Br J Pharmacol. 1969 Jun;36(2):225-39. doi: 10.1111/j.1476-5381.1969.tb09500.x.
8
Interactions of narcotic antagonists and antagonist-analgesics.
J Pharm Pharmacol. 1968 Jul;20(7):547-52. doi: 10.1111/j.2042-7158.1968.tb09803.x.
9
Morphine-induced mydriasis and fluctuation in the rat: time and dose relationships.吗啡诱导大鼠瞳孔散大及波动：时间与剂量关系
J Pharmacol Exp Ther. 1979 Jan;208(1):91-5.
10
Morphine mydriasis in mice.小鼠中的吗啡散瞳作用
Life Sci. 1979 Apr 30;24(18):1667-73. doi: 10.1016/0024-3205(79)90251-0.

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