用放射免疫测定法未能在牛淋巴瘤中检测到可溶性肿瘤相关抗原。
Failure to detect soluble tumor associated antigen by radioimmunoassay in bovine lymphoma.
作者信息
Jacobs R M, Valli V E, Wilkie B N
出版信息
Can J Comp Med. 1981 Jan;45(1):82-6.
Abstract
The detection of circulating soluble tumor-associated antigen by radioimmunoassay was attempted in cows with lymphoma. The assay system did detect PAGE-purified tumor-associated antigen but did not detect immunoreactive substances in the sera of 20 affected animals and 20 normal cattle. Similarly, ultrafiltration of low pH-dissociated serum to separate immune complexes did not aid in the detection of antigen.
摘要
尝试采用放射免疫分析法检测患淋巴瘤奶牛体内循环的可溶性肿瘤相关抗原。该检测系统确实能检测到经聚丙烯酰胺凝胶电泳（PAGE）纯化的肿瘤相关抗原，但在20头患病动物和20头正常牛的血清中未检测到免疫反应性物质。同样，对低pH解离血清进行超滤以分离免疫复合物，也无助于抗原的检测。
相似文献
1
Failure to detect soluble tumor associated antigen by radioimmunoassay in bovine lymphoma.用放射免疫测定法未能在牛淋巴瘤中检测到可溶性肿瘤相关抗原。
Can J Comp Med. 1981 Jan;45(1):82-6.
2
Partial purification of a common antigen in bovine lymphoma and its use in a lymphocyte blastogenesis assay.牛淋巴瘤中一种常见抗原的部分纯化及其在淋巴细胞增殖试验中的应用。
Cancer Res. 1981 Aug;41(8):3000-4.
3
Response of cows with lymphoma to the intradermal injection of tumor cell antigens and phytohemagglutinin.患有淋巴瘤的奶牛对皮内注射肿瘤细胞抗原和植物血凝素的反应。
Can J Comp Med. 1981 Jan;45(1):43-50.
4
Inhibition of lymphocyte blastogenesis by sera from cows with lymphoma.患有淋巴瘤的奶牛血清对淋巴细胞增殖的抑制作用。
Am J Vet Res. 1980 Mar;41(3):372-6.
5
Host response to bovine ocular squamous cell carcinoma.
Am J Vet Res. 1985 Sep;46(9):1975-9.
6
Tumor-associated antigen and cell surface marker in cells of bovine lymphosarcoma.牛淋巴肉瘤细胞中的肿瘤相关抗原和细胞表面标志物
Ann Rech Vet. 1978;9(4):825-30.
7
8
Antibodies to bovine leukemia virus and presence of malignant lymphoma in slaughtered California dairy cattle.
J Natl Cancer Inst. 1985 Mar;74(3):711-4.
9
Detection of circulating immune complexes by the enzyme-linked immunosorbent assay in sera from cattle infected with Fasciola hepatica.
J Parasitol. 1989 Oct;75(5):690-5.
10
Tumor-associated antigen detected by complement-dependent antibody cytotoxicity test and immunofluorescence test in enzootic bovine lymphosarcoma.在地方性牛淋巴肉瘤中通过补体依赖抗体细胞毒性试验和免疫荧光试验检测到的肿瘤相关抗原。
Nihon Juigaku Zasshi. 1983 Apr;45(2):195-202. doi: 10.1292/jvms1939.45.195.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
IMMUNOLOGY OF EXPERIMENTAL TUMORS.实验性肿瘤的免疫学
Annu Rev Med. 1964;15:167-86. doi: 10.1146/annurev.me.15.020164.001123.
3
Inhibition of lymphocyte blastogenesis by sera from cows with lymphoma.患有淋巴瘤的奶牛血清对淋巴细胞增殖的抑制作用。
Am J Vet Res. 1980 Mar;41(3):372-6.
4
Response of cows with lymphoma to the intradermal injection of tumor cell antigens and phytohemagglutinin.患有淋巴瘤的奶牛对皮内注射肿瘤细胞抗原和植物血凝素的反应。
Can J Comp Med. 1981 Jan;45(1):43-50.
5
Suggestive evidence that the "blocking antibodies" of tumor-bearing individuals may be antigen--antibody complexes.有提示性证据表明，荷瘤个体的“封闭抗体”可能是抗原-抗体复合物。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1372-5. doi: 10.1073/pnas.68.6.1372.
6
Blocking of cell-mediated tumor immunity by sera from patients with growing neoplasms.肿瘤生长患者血清对细胞介导的肿瘤免疫的阻断作用。
Int J Cancer. 1971 Mar 15;7(2):226-37. doi: 10.1002/ijc.2910070206.
7
8
Radioimmunoassay of tumour specific transplantation antigen of a chemically induced rat sarcoma: circulating soluble tumour antigen in tumour bearers.化学诱导大鼠肉瘤肿瘤特异性移植抗原的放射免疫测定：荷瘤动物体内的循环可溶性肿瘤抗原
Br J Cancer. 1973 Nov;28(5):377-88. doi: 10.1038/bjc.1973.163.
9
The presence of tumour-specific membrane antigen in the serum of rats with chemically induced sarcomata.化学诱导肉瘤大鼠血清中肿瘤特异性膜抗原的存在。
Br J Cancer. 1973 Jan;27(1):27-34. doi: 10.1038/bjc.1973.4.
10
Comparison of direct and indirect solid-phase microradioimmunoassays for the detection of viral antigens and antiviral antibody.用于检测病毒抗原和抗病毒抗体的直接和间接固相微放射免疫测定法的比较。
Appl Microbiol. 1973 Apr;25(4):567-73. doi: 10.1128/am.25.4.567-573.1973.
Zotero 插件