患有淋巴瘤的奶牛对皮内注射肿瘤细胞抗原和植物血凝素的反应。
Response of cows with lymphoma to the intradermal injection of tumor cell antigens and phytohemagglutinin.
作者信息
Jacobs R M, Valli V E, Wilkie B N
出版信息
Can J Comp Med. 1981 Jan;45(1):43-50.
Tumor cell-membrane antigens did not elicit specific intradermal reactions in cows with lymphoma and were therefore not effective in identifying animals with tumor. Sixty-two percent (8/13) of cows with lymphoma in the advanced stages of disease responded poorly to the intradermal injection of a nonspecific mitogen (PHA-M) and normal lymphoid cell extracts. This finding may explain the lack of response to the tumor cell extracts that some cows with lymphoma and indicates the presence of immune deficits in animals with lymphoma. Six of eight animals with tumor and poor cutaneous sensitivity had sera that inhibited the blastogenesis of normal lymphocytes. The presence of this inhibitory material is associated with the presence of tumor, not with bovine leukemia virus infection and partially accounts for the relative cutaneous anergy in cattle with lymphoma.
肿瘤细胞膜抗原在患有淋巴瘤的奶牛中未引发特异性皮内反应，因此在识别患有肿瘤的动物方面无效。处于疾病晚期的淋巴瘤奶牛中有62%（8/13）对皮内注射非特异性丝裂原（PHA-M）和正常淋巴细胞提取物反应不佳。这一发现可能解释了一些淋巴瘤奶牛对肿瘤细胞提取物缺乏反应的原因，并表明淋巴瘤动物存在免疫缺陷。八只患有肿瘤且皮肤敏感性差的动物中有六只的血清抑制正常淋巴细胞的增殖。这种抑制性物质的存在与肿瘤的存在有关，与牛白血病病毒感染无关，部分解释了淋巴瘤牛相对皮肤无反应性的原因。
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