非燕麦细胞肺癌中剂量-时间-分割方案的比较。

Comparison of dose-time-fractionation schemes in non-oat cell lung cancer.

作者信息

Shah K, Olson M H, Ray P, Wright A E

出版信息

Cancer. 1981 Sep 1;48(5):1127-32. doi: 10.1002/1097-0142(19810901)48:5<1127::aid-cncr2820480514>3.0.co;2-9.

DOI:10.1002/1097-0142(19810901)48:5<1127::aid-cncr2820480514>3.0.co;2-9

Abstract

A series of 205 patients with inoperable, non-oat cell carcinoma of the lung were treated with three different dose-fractionation schedules. Fifty-six patients received 5000 rads in 25 fractions over five weeks (continuous, A); 79 patients received 2000 rads in five fractions over five days, with two weeks' rest, followed by 2000 rads in five fractions over five days (split-course, B); 70 patients received 3000 rads in 10 fractions over two weeks, followed by three weeks' rest and another 3000 rads (split course, C). The 24-month survival was 33% for A, 15% for B and 25% for C. The split course was better tolerated and radiation fibrosis was dose-related.

摘要

对205例无法手术的非燕麦细胞肺癌患者采用三种不同的剂量分割方案进行治疗。56例患者在五周内分25次接受5000拉德（连续照射，方案A）；79例患者在五天内分5次接受2000拉德，休息两周后，再在五天内分5次接受2000拉德（分段疗程，方案B）；70例患者在两周内分10次接受3000拉德，休息三周后再接受3000拉德（分段疗程，方案C）。方案A的24个月生存率为33%，方案B为15%，方案C为25%。分段疗程的耐受性更好，放射性纤维化与剂量相关。