原发性乳腺癌中1号染色体长臂的优先受累情况。

Preferential involvement of chromosome 1q in a primary breast carcinoma.

作者信息

Kovacs G

出版信息

Cancer Genet Cytogenet. 1981 Mar;3(2):125-9. doi: 10.1016/0165-4608(81)90066-2.

Abstract

The cytogenetic findings by G- and C-banding in a primary breast carcinoma are reported. The tumor is characterized by a high modal number of chromosomes (79) and 14 markers of ten different origins. Chromosome #1 is more frequently involved in structural and numerical aberrations than is any other chromosome; nine copies of 1q were present in each cell examined. This observation supports the hypothesis that duplication of chromosome 1q may play an important role in the progression of malignant tumors.

摘要

报道了原发性乳腺癌经G显带和C显带后的细胞遗传学发现。该肿瘤的特征是染色体众数较高（79条）以及有14条源自10个不同来源的标记染色体。与其他任何染色体相比，1号染色体更频繁地发生结构和数量畸变；在所检测的每个细胞中都存在9个1q拷贝。这一观察结果支持了1q染色体重复可能在恶性肿瘤进展中起重要作用的假说。