Kross J, Schulman P, Kardon N, Budman D, Vinciguerra V, Degnan T
Cancer Genet Cytogenet. 1981 Mar;3(2):155-9. doi: 10.1016/0165-4608(81)90071-6.
Myelodysplasia and acute nonlymphocytic leukemia following therapy for Hodgkin's disease are observed rather frequently. Herein, we describe a patient with this syndrome treated with prolonged chemotherapy (alone), having a monosomy 7 karyotype. Cytogenetic studies were performed serially during the myelodysplasia preceding overt leukemia. Review of the literature and relevance of these findings are discussed.
霍奇金病治疗后发生骨髓发育异常和急性非淋巴细胞白血病的情况较为常见。在此，我们描述了一名患有该综合征的患者，接受了长期化疗（单独化疗），其核型为7号染色体单体。在明显白血病之前的骨髓发育异常阶段连续进行了细胞遗传学研究。并讨论了文献综述及这些发现的相关性。
