Zaccaria A, Rosti G, Testoni N, Mazza P, Cantore M, Tura S
Cancer Genet Cytogenet. 1983 Jul;9(3):217-26. doi: 10.1016/0165-4608(83)90004-3.
The clinical, hematological, and cytogenetical features of six patients with hematological disorders secondary to Hodgkin's lymphoma (HL), are described. Three patients developed a dysmyelopoietic syndrome (DMS); three, an acute nonlymphocytic leukemia (ANLL). Chromosomal analyses showed a normal karyotype in one case and an abnormal one in five cases: one with a 53-chromosome clone, two with a pseudodiploid pattern plus hyperdiploid subclones, and two with a hypodiploid pattern. Trisomy 21 was observed in two cases, tetrasomy 21 in one case, monosomy 5 and monosomy 7 in two cases. The correlations of chromosomal changes with hematological abnormalities or clinical aspects are discussed.
本文描述了6例继发于霍奇金淋巴瘤（HL）的血液系统疾病患者的临床、血液学及细胞遗传学特征。3例患者发生了骨髓生成异常综合征（DMS）；3例发生了急性非淋巴细胞白血病（ANLL）。染色体分析显示，1例核型正常，5例异常：1例为53条染色体克隆，2例为假二倍体模式加超二倍体亚克隆，2例为亚二倍体模式。2例观察到21三体，1例观察到21四体，2例观察到5号染色体单体和7号染色体单体。本文还讨论了染色体变化与血液学异常或临床情况之间的相关性。
