Harrison L I, Chang S F, Welscher T M, Ober R E
Clin Ther. 1981;4(1):18-23.
This single-dose, three-way crossover study in 18 healthy adults compared the oral absorption of theophylline from a theophylline-guaifenesin tablet and from a theophylline-guaifenesin liquid with absorption from a theophylline liquid. Each dose form contained 500 mg theophylline and, when indicated, 400 mg guaifenesin. The extents of theophylline absorption from the formulations were within 10% of each other. The absolute differences in the areas under the curve among the formulations were small and, although significantly higher statistically for the theophylline-guaifenesin tablet, are without therapeutic consequence. The theophylline plasma level curves from each of the three formulations were similar. Comparable theophylline absorption and elimination characteristics were seen.
这项针对18名健康成年人的单剂量、三向交叉研究比较了氨茶碱-愈创甘油醚片剂、氨茶碱-愈创甘油醚液剂中氨茶碱的口服吸收情况与氨茶碱液剂的吸收情况。每种剂型都含有500毫克氨茶碱，如有说明则含有400毫克愈创甘油醚。各制剂中氨茶碱的吸收程度相互之间相差不超过10%。各制剂曲线下面积的绝对差异很小，尽管氨茶碱-愈创甘油醚片剂在统计学上显著更高，但并无治疗上的影响。三种制剂的氨茶碱血浆水平曲线相似。观察到了相似的氨茶碱吸收和消除特征。
