Bolognesi C, Cesarone C F, Santi L
Carcinogenesis. 1981;2(4):265-8. doi: 10.1093/carcin/2.4.265.
The time course of DNA damage induced by in vivo administration of benzidine, 1- and 2-naphthylamine or dimethylnaphthylamine has been evaluated using an alkaline elution technique. The organs damaged by the active ultimate metabolites, produced in mice treated with aromatic amines, appear to be, in decreasing order of susceptibility, liver, kidney and lung. Single-stranded DNA breaks are still evident 12 h after a single administered dose of the compounds. A direct dose-response relationship has been obtained using increasing concentrations of aromatic amines.
使用碱性洗脱技术评估了体内给予联苯胺、1-萘胺、2-萘胺或二甲基萘胺所诱导的DNA损伤的时间进程。在用芳香胺处理的小鼠中产生的活性终末代谢产物所损伤的器官，按易感性降低的顺序似乎是肝脏、肾脏和肺。单次给予这些化合物后12小时，单链DNA断裂仍然明显。使用递增浓度的芳香胺已获得直接的剂量反应关系。
