Schultz J S, Good A E, Sing C F, Kapur J J
Clin Genet. 1981 Mar;19(3):159-67. doi: 10.1111/j.1399-0004.1981.tb00690.x.
The analysis of the clinical and HLA profiles of 99 patients with Reiter's syndrome is reported. Antigen HLA-B27, which has previously been firmly associated with Reiter's syndrome, predisposes patients to develop disease features which reflect articular involvement. The HLA haplotype A2, B27 was found to be at an elevated frequency in our Reiter's syndrome sample, and the latter two antigens are also associated with a general increase in disease severity. Conversely, antigen BW35 appears to be protective against certain features of the syndrome. Patients with certain antigenic profiles (namely A2 and A3 together with B27) tend to develop certain syndrome manifestations earlier in the course of the disease than those with other antigens.
报告了对99例赖特综合征患者的临床和HLA谱分析。先前已与赖特综合征紧密相关的抗原HLA - B27，使患者易出现反映关节受累的疾病特征。在我们的赖特综合征样本中发现HLA单倍型A2、B27的频率升高，而后两种抗原也与疾病严重程度的总体增加有关。相反，抗原BW35似乎对该综合征的某些特征具有保护作用。具有某些抗原谱（即A2和A3以及B27）的患者在疾病过程中往往比具有其他抗原的患者更早出现某些综合征表现。
