Garrett M J
Clin Radiol. 1981 Sep;32(5):537-42. doi: 10.1016/s0009-9260(81)80183-3.
This report reviews the common complications associated with the investigation and treatment of the lymphomas and enumerates the complications recorded so far in the 1410 patients with Hodgkin's disease registered in the British National Lymphoma Investigation. Long-term follow-up of these patients will allow a better understanding of the overall risks of splenectomy. The incidence of leukaemia and other lymphomas in the group of patients studied in the BNLI is extremely low. Two patients developed non-Hodgkin's lymphomas, one having had radiotherapy alone and the other MOPP alone. Two patients developed acute myeloid leukaemia, one after mantle radiotherapy followed by chemotherapy and one after MOPP alone. A fifth patient treated with MOPP alone developed a rapidly fatal acute lymphatic leukaemia three years later. This low incidence of second malignancies may be related to the relatively non-aggressive treatment schedules utilised by the BNLI.
本报告回顾了淋巴瘤诊断和治疗过程中常见的并发症，并列举了英国国家淋巴瘤研究中登记的1410例霍奇金病患者目前记录的并发症。对这些患者的长期随访将有助于更好地了解脾切除术的总体风险。在英国国家淋巴瘤研究中所研究的患者组中，白血病和其他淋巴瘤的发病率极低。两名患者发生了非霍奇金淋巴瘤，一名仅接受了放疗，另一名仅接受了MOPP方案化疗。两名患者发生了急性髓细胞白血病，一名在斗篷野放疗后化疗，另一名仅接受了MOPP方案化疗。第五名仅接受MOPP方案化疗的患者三年后发生了迅速致命的急性淋巴细胞白血病。第二原发恶性肿瘤的低发病率可能与英国国家淋巴瘤研究采用的相对温和的治疗方案有关。
