Moglia A, Tartara A, Arrigo A, Poggi P, Scelsi M, Scelsi R
Farmaco Sci. 1981 Jun;36(6):419-24.
60 albino Sprague-Dawley female rats, 250 g of body weight, were treated for 6 months with phenytoin 30 mg/100 g/die per os (mean plasma levels: 10-20 gamma/ml). Between 75 and 90 days of treatment motor and sensory nerve conduction velocities were examined along the tail (Miyoshi and Goto, 1973; Fiaschi et al., 1977) in 15 treated animals and in 10 untreated control animals. A slowing of sensory conduction velocity was shown in 6 treated animals (40%); in 2 of them (13%) the motor conduction velocity was also showed. 25 treated rats were controlled with the same neurophysiologic methods after 165-180 days of PHT treatment in comparison with 10 controls; a slowing of sensory conduction velocity was observed in 14 treated rats (56%) and a slowing of motor conduction in 5 of them (20%). The hystological and ultrastructural study carried out on the sciatic nerves of all animals revealed changes of myelinated fibres only in the animals with slowed motor conduction velocity. The non-myelinated fibres were apparently normal.
60只体重250克的白化斯普拉格-道利雌性大鼠，口服苯妥英30毫克/100克/日，持续治疗6个月（平均血浆水平：10 - 20微克/毫升）。在治疗75至90天时，对15只治疗动物和10只未治疗对照动物沿尾巴检查运动和感觉神经传导速度（Miyoshi和Goto，1973；Fiaschi等人，1977）。6只治疗动物（40%）出现感觉传导速度减慢；其中2只（13%）运动传导速度也减慢。在苯妥英治疗165 - 180天后，用相同神经生理学方法对25只治疗大鼠与10只对照大鼠进行对照；14只治疗大鼠（56%）出现感觉传导速度减慢，其中5只（20%）出现运动传导减慢。对所有动物坐骨神经进行的组织学和超微结构研究显示，仅在运动传导速度减慢的动物中有髓纤维发生变化。无髓纤维明显正常。
