Pastoris O, Raimondo S, Dossena M, Fulle D
Farmaco Sci. 1981 Aug;36(8):721-8.
The effects of uridine-5'-diphosphoglucose (UDPG) on the contractile response of the phrenic nerve-diaphragm preparation and on carbohydrate metabolism in the diaphragmatic muscle were studied in the rat. In the preparations obtained form rats, the contracturant action of UDPG, previously observed in guinea-pig preparations, was thus confirmed. This action was compared with those of uridine, UMP and UDP. Uridine alone was ineffective, while the higher concentration of both UMP and UDP induced a contracture comparable with that shown for the lower concentration of UDPG. This indicates that the action of UDPG is partially related at least to one phosphate-group into its molecular structure. In addition, several substrates and intermediates related to carbohydrate metabolism (glycogen, glucose, glucose-6-phosphate) were measured in the diaphragm, their concentrations proving unaffected by UDPG perfusion.
在大鼠中研究了尿苷-5'-二磷酸葡萄糖（UDPG）对膈神经-膈肌标本收缩反应及膈肌碳水化合物代谢的影响。在取自大鼠的标本中，证实了先前在豚鼠标本中观察到的UDPG的致挛作用。将该作用与尿苷、UMP和UDP的作用进行了比较。单独的尿苷无效，而较高浓度的UMP和UDP诱导的挛缩与较低浓度的UDPG所引起的挛缩相当。这表明UDPG的作用至少部分与其分子结构中的一个磷酸基团有关。此外，测定了膈肌中与碳水化合物代谢相关的几种底物和中间产物（糖原、葡萄糖、6-磷酸葡萄糖），结果表明它们的浓度不受UDPG灌注的影响。
