Pastoris O, Dossena M, Raimondo S, Tanzi F
Farmaco Sci. 1979 Mar;34(3):211-6.
The action of uridine-5'-diphosphoglucose (UDPG) on the contractile response of the phrenic diaphragm preparation from guinea pig was investigated. UDPG activity was assayed on the preparation at rest or during the exercise; in this case indirect electrical stimulation of phrenic diaphragm preparation or direct stimulation of denervated or curarized muscle were employed. Krebs' solutions adequately modified with regard to glucose concentration were used. The effect of UDPG on the neuromuscular junction was also investigated by recording miniature end plate potentials. An effect of the drug on neuromuscular transmission and on glucose metabolism could be demonstrated.
研究了尿苷-5'-二磷酸葡萄糖（UDPG）对豚鼠膈神经膈肌标本收缩反应的作用。在标本静止或运动时测定UDPG活性；在这种情况下，采用膈神经膈肌标本的间接电刺激或对去神经或箭毒化肌肉的直接刺激。使用了在葡萄糖浓度方面经过适当改良的克雷布斯溶液。还通过记录微小终板电位来研究UDPG对神经肌肉接头的作用。可以证明该药物对神经肌肉传递和葡萄糖代谢有作用。
