病毒性肝病与肝组织中的微粒体芳基酰胺酶活性

Viral hepatic diseases and microsomal arylamidase activity in liver tissue.

作者信息

Itoh S, Satoh T, Tsukada Y, Matsuo S, Ichinoe A

出版信息

Digestion. 1981;22(2):57-60. doi: 10.1159/000198595.

DOI:10.1159/000198595

Abstract

The relationship between microsomal arylamidase activity, determined by a micromethod, and changes of hepatocytes was studied in biopsy samples taken from 107 patients with normal liver histology and viral hepatic diseases. The activities in healthy carriers and chronic persistent hepatitis patients were significantly greater than those of controls, acute hepatitis and chronic active hepatitis patients, and showed a significant greater than those of controls, acute hepatitis and chronic active hepatitis patients, and showed a significant correlation to morphologic criteria. Ultrastructurally, regularly increased smooth endoplasmic reticulum (SER) was found especially in healthy carriers. The arylamidase activity reflects virus-induced changes of the SER in healthy carriers and viral hepatic diseases.

摘要

采用微量法测定微粒体芳基酰胺酶活性，并研究其与肝细胞变化之间的关系。研究对象为107例肝脏组织学正常及患有病毒性肝病的患者，所取活检样本来自这些患者。健康携带者和慢性持续性肝炎患者的酶活性显著高于对照组、急性肝炎和慢性活动性肝炎患者，且与形态学标准显著相关。超微结构上，尤其在健康携带者中发现了规则增加的滑面内质网（SER）。芳基酰胺酶活性反映了健康携带者和病毒性肝病中病毒诱导的SER变化。