Stibbe J, van der Plas P M, Ong G L, ten Hoor F, Nauta J, de Jong D S, Krenning-Douma E, Gomes M
Haemostasis. 1981;10(5):276-88. doi: 10.1159/000214411.
The effect of some gelatin plasma substitutes (Haemaccel, plasmagel and Plasmion (Geloplasma), which are widely used in Europe) on collagen-, ADP- and adrenaline-induced platelet aggregation in human PRP in vitro was studied under controlled conditions (pH, electrolyte composition). Haemaccel inhibited these aggregations, both in citrated as well as in heparinised PRP, whereas they were enhanced by both Plasmagel and Plasmion as compared to the appropriate control. Increasing teh concentration of the inducer overcame the inhibition by Haemaccel. Haemaccel inhibited, while Plasmion enhanced 14C-serotonin release induced by collagen, ADP or adrenaline. Also in the presence of indomethacin (90 muM) Haemaccel inhibited aggregation induced by high concentrations of collagen and the primary aggregation induced by ADP and adrenaline, while Plasmion enhanced these aggregations induced by ADP and adrenaline, while Plasmion enhanced these aggregations. The inhibition by Haemaccel was not caused by binding of Ca2+ to haemaccel.
在可控条件下（pH值、电解质成分），研究了一些在欧洲广泛使用的明胶血浆代用品（贺斯、血浆凝胶和血浆明胶（凝胶血浆））对人富血小板血浆（PRP）中胶原蛋白、ADP和肾上腺素诱导的血小板聚集的影响。贺斯在枸橼酸化PRP和肝素化PRP中均抑制这些聚集，而与相应对照相比，血浆凝胶和血浆明胶均增强了这些聚集。增加诱导剂浓度可克服贺斯的抑制作用。贺斯抑制，而血浆明胶增强胶原蛋白、ADP或肾上腺素诱导的14C - 5 -羟色胺释放。同样在吲哚美辛（90μM）存在的情况下，贺斯抑制高浓度胶原蛋白诱导的聚集以及ADP和肾上腺素诱导的初始聚集，而血浆明胶增强ADP和肾上腺素诱导的这些聚集。贺斯的抑制作用不是由Ca2 +与贺斯结合引起的。
