Glusa E, Markwardt F
Haemostasis. 1980;9(3):188-92. doi: 10.1159/000214357.
The anticoagulant used for blood collection may modify platelet aggregation. In platelet-rich citrated plasma, adrenaline induced biphasic aggregation accompanied by 14C-serotonin release, whereas in platelet-rich hirudin plasma it induced weak primary aggregation. In plasma from blood anticoagulated simultaneously with hirudin and citrate, adrenaline caused biphasic aggregation as it was observed in citrated plasma. Qualitative differences in platelet reaction in hirudin citrated plasma were found to be dependent on calcium ion concentration. Therefore, the deprivation of calcium ions by citrate is considered the cause of the adrenaline effect in citrated plasma.
用于血液采集的抗凝剂可能会改变血小板聚集。在富含血小板的枸橼酸盐血浆中，肾上腺素诱导双相聚集并伴有14C - 5 -羟色胺释放，而在富含血小板的水蛭素血浆中，它诱导微弱的初级聚集。在同时用水蛭素和枸橼酸盐抗凝的血液的血浆中，肾上腺素引起双相聚集，正如在枸橼酸盐血浆中观察到的那样。发现在水蛭素枸橼酸盐血浆中血小板反应的定性差异取决于钙离子浓度。因此，枸橼酸盐导致的钙离子缺失被认为是枸橼酸盐血浆中肾上腺素效应的原因。
