Mitsuyama Y, Yamamoto T
Folia Psychiatr Neurol Jpn. 1981;35(1):89-101. doi: 10.1111/j.1440-1819.1981.tb00204.x.
A neuropathologic study, chiefly cerebrovascular lesions and degenerative changes, was conducted on the brains of 233 subjects 50 years of age and over among 557 autopsy cases of RERF-ABCC Hiroshima in 1972-1974. There were some discrepancies between the principal clinical diagnosis and principal pathologic diagnosis in cerebrovascular disease. For cerebral hemorrhage, 8.6% were accounted for in the clinical diagnosis of the entire subjects while only 2.1% were accounted for in the pathologic diagnosis of the same subject. The degenerative changes in the central nervous system have been increasing with age and these changes were seen more in the females than in the males. Intracerebral arteriosclerosis of a moderate extension or more existed in 36.5% of the subjects and the frequency of this disease increased with age. the frequency of cerebral infarct increased with age. The location of the infarcts was most often seen in the basal ganglia and cortex of cerebrum, the size of the cortical infarct was within 0.5 cm in diameter and multiple. The vascular lesions or degenerative changes were seen in about 74% of the brains of 50 years and over.
1972年至1974年，对日本原爆病资料中心（RERF-ABCC）广岛分所557例尸检病例中233例50岁及以上受试者的大脑进行了一项神经病理学研究，主要针对脑血管病变和退行性变化。脑血管疾病的主要临床诊断和主要病理诊断之间存在一些差异。对于脑出血，在全部受试者的临床诊断中占8.6%，而在同一受试者的病理诊断中仅占2.1%。中枢神经系统的退行性变化随年龄增长而增加，女性比男性更常见。中度及以上的脑内动脉硬化在36.5%的受试者中存在，且该疾病的发生率随年龄增长而增加。脑梗死的发生率随年龄增长而增加。梗死灶最常出现在基底节和大脑皮质，皮质梗死灶直径在0.5厘米以内且为多发。50岁及以上受试者中约74%的大脑出现血管病变或退行性变化。
