Mitsuyama Y, Thompson L R, Hayashi T, Lee K K, Keehn R J, Resch J A, Steer A
Stroke. 1979 Jul-Aug;10(4):389-95. doi: 10.1161/01.str.10.4.389.
Evidence of cerebrovascular disease at autopsy was compared in 2 groups of men: 186 long-time residents of Hiroshima, Japan, and 253 men of Japanese ancestry long resident in Honolulu, Hawaii. They were 45 to 71 years-of-age at death. Atherosclerosis of the circle of Willis and its major branches, sclerosis of the intraparenchymal arteries and the frequency of cerebral hemorrhage and cerebral infarct were compared in the 2 populations. The Honolulu subjects had significantly more atherosclerosis of the circle of Willis, but less intraparenchymal artery sclerosis and less cerebral infarction. Cerebral hemorrhage was equally frequent in the 2 cities. It was concluded that cerebral infarction is more frequent in Japanese men in Hiroshima than Honolulu, and that men of Japanese ancestry in Honolulu are spared an appreciable risk of cerebral infarction through decreased frequency of intraparenchymal arterial sclerosis despite higher levels of atherosclerosis of large intracranial arteries.
一组是186名日本广岛的长期居民，另一组是253名长期居住在夏威夷檀香山的日裔男性。他们死亡时的年龄在45至71岁之间。比较了这两个人群中 Willis 环及其主要分支的动脉粥样硬化、脑实质内动脉的硬化以及脑出血和脑梗死的发生率。檀香山的受试者 Willis 环的动脉粥样硬化明显更多，但脑实质内动脉硬化较少，脑梗死也较少。脑出血在两个城市的发生率相同。得出的结论是，广岛的日本男性脑梗死比檀香山更常见，檀香山的日裔男性尽管颅内大动脉的动脉粥样硬化水平较高，但由于脑实质内动脉硬化频率降低，可避免相当大的脑梗死风险。
