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经导管肺动脉电凝术:用于研究肺血栓形成的犬实验模型

Transcatheter electrocoagulation of the pulmonary artery: an experimental model in dogs for studying pulmonary thrombosis.

作者信息

McAlister D S, Pizzo S, Putman C E, Thompson W M

出版信息

Invest Radiol. 1981 Jul-Aug;16(4):289-97. doi: 10.1097/00004424-198107000-00009.

DOI:10.1097/00004424-198107000-00009
PMID:7275541
Abstract

Transcatheter electrocoagulation (TCEC) has been shown to produce permanent arterial occlusion. This study was performed to evaluate the potential of using TCEC of the pulmonary artery as an experimental model of pulmonary thromboembolism. Fourteen lobar or first-order pulmonary arteries were occluded in ten dogs in the acute studies. Eight pulmonary arteries were occluded in eight dogs that were sacrificed 25 to 85 days after TCEC. There were permanent occlusions in seven, and all seven evidence of pulmonary infarction. The animals tolerated the procedure well. The technique may have merit as an experimental model for studying pulmonary thrombosis and infarction.

摘要

经导管电凝术(TCEC)已被证明可产生永久性动脉闭塞。本研究旨在评估将肺动脉经导管电凝术用作肺血栓栓塞实验模型的潜力。在急性研究中,对10只狗的14个叶或一级肺动脉进行了闭塞。在经导管电凝术后25至85天处死的8只狗中,有8个肺动脉被闭塞。其中7个出现永久性闭塞,且所有7个都有肺梗死的证据。动物对该操作耐受性良好。该技术作为研究肺血栓形成和梗死的实验模型可能具有价值。

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