Thompson W M, Pizzo S V, Jackson D C, Johnsrude I S
Invest Radiol. 1977 Mar-Apr;12(2):146-53. doi: 10.1097/00004424-197703000-00008.
Previous work has shown that localized electrocoagulation of blood vessels using direct current applied by catheter placed electrodes is feasible. In vitro and in vivo experiments showed that clot size and thrombosis of vessels are directly related to the product of the amount and duration of the current. Surgically created splenic hemorrhage was well controlled in 9 of 10 animals. The vessels remained permanently occluded after electrocoagulation in 8 of 9 animals. Pathological studies of all the vessels showed intimal damage at the sites of occlusion. These experiments indicate that clot formation may be a product of both intimal damage and platelet attraction to the positive electrode. The technique has advantages over embolization since no foreign material is injected and a localized clot is produced at the tip of the guidewire. There are certain disadvantages and further refinements must be developed to establish transcatheter electrocoagulation as a useful clinical technique for vessel occlusion.
先前的研究表明，使用置于导管的电极施加直流电对血管进行局部电凝是可行的。体外和体内实验表明，血凝块大小和血管血栓形成与电流的量和持续时间的乘积直接相关。在10只动物中，有9只动物通过手术造成的脾出血得到了良好控制。在9只动物中，有8只动物在电凝后血管保持永久性闭塞。对所有血管的病理研究显示，闭塞部位存在内膜损伤。这些实验表明，血栓形成可能是内膜损伤和血小板向正极吸引的共同结果。该技术优于栓塞术，因为无需注入异物，并且在导丝尖端产生局部血栓。该技术存在一定的缺点，必须进一步改进，才能将经导管电凝确立为一种用于血管闭塞的实用临床技术。
