Green C E, Higgins C B, Kelley M J, Schmidt W S, Haigler F H, Newell J D
Invest Radiol. 1981 Jul-Aug;16(4):324-9. doi: 10.1097/00004424-198107000-00014.
Rapid administration of protamine sulfate after arteriography or cardiopulmonary bypass has occasionally been associated with marked hypotension. Since it is unclear whether this is due entirely to vasodilatation or to myocardial depression in addition to vasodilatation, the authors assessed the direct myocardial and systemic circulatory effects of this drug in seven anesthetized dogs. Direct effects of protamine sulfate on global and regional myocardial function and peripheral arterial resistance were determined in the presence and absence of segmental myocardial ischemia. Effects on the myocardium were determined by intracoronary administration of protamine; effects on the systemic circulation were determined after intravenous administration. Intracoronary administration of protamine caused no significant change in left ventricular contractility in either the normal or ischemic state. Intravenous administration produced hypotension due to peripheral vasodilation.
在动脉造影或体外循环后快速给予硫酸鱼精蛋白偶尔会伴有显著的低血压。由于尚不清楚这是否完全归因于血管扩张，还是除血管扩张外还伴有心肌抑制，作者评估了该药物对7只麻醉犬的直接心肌和全身循环效应。在有和没有节段性心肌缺血的情况下，测定了硫酸鱼精蛋白对整体和局部心肌功能以及外周动脉阻力的直接影响。通过冠状动脉内给予鱼精蛋白来测定对心肌的影响；通过静脉内给药后测定对全身循环的影响。冠状动脉内给予鱼精蛋白在正常或缺血状态下均未引起左心室收缩力的显著变化。静脉内给药由于外周血管扩张而导致低血压。
