一项基于医院的纳瓦霍族和霍皮族印第安人放射性骶髂关节炎、HLA - B27及Cw2的调查。

A hospital-based survey of radiological sacroiliitis and HLA-B27 and Cw2 in Navajo and Hopi Indians.

作者信息

Kuberski T T, Morse H G, Rate R G, Bonnell M D, Wood J G, Bennett P H

出版信息

Hum Immunol. 1981 Aug;3(1):77-83. doi: 10.1016/0198-8859(81)90045-8.

Abstract

The frequency of radiological sacroiliitis and its association with HLA-B27, Cw1, and Cw2 were determined in Navajo and Hopi Indians coming to a community hospital. In the Navajo, the phenotype frequency of HLA-B27 was 36% and the frequency of sacroiliitis, 11%. In contrast, among the Hopi, the phenotype frequency of HLA-B27 was 9% and the frequency of sacroiliitis, 4%. Of the Navajo men, who had sacroiliitis and were HLA typed, 83% were HLA-B27 positive. The increased frequency of radiological sacroiliitis and were HLA typed, 83% were HLA-B27 positive. The increased frequency of radiological sacroiliitis in the Navajo was felt to be related to the high frequency of HLA-B27 and Reiter's syndrome in this population. HLA-B27, HLA-Cw1, and HLA-Cw2 are known to be in linkage disequilibrium, and about one-half of the men with sacroiliitis from both tribes had concurrence of HLA-B27 and HLA-Cw2.

摘要

对一家社区医院收治的纳瓦霍族和霍皮族印第安人进行了放射学骶髂关节炎的发病率及其与HLA - B27、Cw1和Cw2相关性的测定。在纳瓦霍族中，HLA - B27的表型频率为36%，骶髂关节炎的频率为11%。相比之下，在霍皮族中，HLA - B27的表型频率为9%，骶髂关节炎的频率为4%。在已进行HLA分型的患骶髂关节炎的纳瓦霍族男性中，83%为HLA - B27阳性。放射学骶髂关节炎发病率的增加以及进行了HLA分型，83%为HLA - B27阳性。纳瓦霍族放射学骶髂关节炎发病率的增加被认为与该人群中HLA - B27和赖特综合征的高频率有关。已知HLA - B27、HLA - Cw1和HLA - Cw2处于连锁不平衡状态，两个部落中约一半患骶髂关节炎的男性同时存在HLA - B27和HLA - Cw2。