Hoyt C S, Billson F A, Alpins N
Ann Ophthalmol. 1978 Nov;10(11):1487-92.
Five patients with kernicterus and ocular motility disturbances are reported. All of the patients showed some defect in vertical gaze but not always upgaze. The most severely affected patient exhibited slowness of horizontal saccades in addition to a total vertical gaze palsy. In general, the severity of the ocular motility disturbance paralleled the severity of hearing loss. It is suggested that damage to the periaqueductal area accounts for disturbances in vertical gaze and the infrequent horizontal saccadic disturbances results from interruption of the descending centrifugal fibers. It is emphasized that kernicterus must be included in the differential diagnosis of any supranuclear vertical gaze disturbance.
报告了5例患有核黄疸和眼球运动障碍的患者。所有患者均表现出垂直注视方面的某些缺陷，但并非总是向上注视缺陷。受影响最严重的患者除完全性垂直注视麻痹外，还表现出水平扫视缓慢。一般来说，眼球运动障碍的严重程度与听力损失的严重程度平行。提示导水管周围区域的损伤导致垂直注视障碍，而罕见的水平扫视障碍是由下行离心纤维中断所致。强调在任何核上性垂直注视障碍的鉴别诊断中都必须考虑核黄疸。
