Gerber L H, Rooney P J, McCarthy D M
J Clin Gastroenterol. 1981 Mar;3(1):7-11. doi: 10.1097/00004836-198103000-00002.
To evaluate the effect of anti-inflammatory drug therapy on ulcer healing, we studied retrospectively patient records listing the dual diagnoses of rheumatoid arthritis and peptic ulcer (1953-1975). Forty-three ulcers (23 gastric and 20 duodenal) occurred in 41 subjects. Evaluation of ulcer healing was possible in 35 patients, 27 of whom had continued on anti-inflammatory drug therapy while being treated for ulcer disease and eight who did not. In 21 of the 27 patients the ulcer healed; in six the ulcer failed to heal, including one who died from gastric carcinoma. Fourteen of the 21 patients whose ulcer healed were taking both aspirin and corticosteroids; in all eight patients who stopped taking anti-inflammatory drugs, the ulcers (eight gastric, one duodenal) healed. In six patients no evaluating was possible because the outcome of ulcer therapy was unknown. The numbers of patients not studied, unlisted or unretrieved are unknown, though probably small, and while no data are available on controls drawn from the same population or on the rates of spontaneous ulcer healing and recurrence in this population, our study nevertheless establishes that ulcer healing does occur in many patients with rheumatoid arthritis despite continued treatment with salicylate, corticosteroid, or other anti-inflammatory drugs.
为评估抗炎药物治疗对溃疡愈合的影响，我们回顾性研究了列出类风湿性关节炎和消化性溃疡双重诊断的患者记录（1953 - 1975年）。41名受试者出现了43处溃疡（23处胃溃疡和20处十二指肠溃疡）。35名患者的溃疡愈合情况可评估，其中27名患者在接受溃疡病治疗时继续使用抗炎药物，8名患者未使用。27名患者中有21名溃疡愈合；6名患者溃疡未愈合，其中1名死于胃癌。溃疡愈合的21名患者中有14名同时服用阿司匹林和皮质类固醇；在停止服用抗炎药物的所有8名患者中，溃疡（8处胃溃疡，1处十二指肠溃疡）均愈合。6名患者因溃疡治疗结果未知而无法评估。未研究、未列出或未找回的患者数量未知，尽管可能很少，而且虽然没有来自同一人群的对照数据，也没有该人群中溃疡自然愈合和复发率的数据，但我们的研究仍然表明，尽管继续使用水杨酸盐、皮质类固醇或其他抗炎药物治疗，许多类风湿性关节炎患者的溃疡确实会愈合。
