Edwards D J, Rimmer J J, Atkinson M J, Perris A D
J Endocrinol. 1981 Sep;90(3):445-52. doi: 10.1677/joe.0.0900445.
When rats or mice were immunized with sheep red blood cells, bacterial lipopolysaccharides or bovine serum albumin, a proliferative response could be detected in the bone marrow and spleen. This response was associated with a hypercalcaemic phase. Parathyroidectomy, which resulted in a protracted hypocalcaemia, prevented the development of an increase in levels of plasma calcium. This operation also prevented the rise in bone marrow proliferations following antigenic challenge, but did not ablate the normal proliferative response to antigen by cells in the spleen. Antibody production and numbers of antibody-forming cells were not significantly reduced by parathyroidectomy. These results suggest that there is a pool of antigen-insensitive cells in the bone marrow which are stimulated after antigenic challenge. It is postulated that these events were mediated by the development of a parathyroid-dependent hypercalcaemia which stimulates the cells non-specifically. These events may form part of a cellular homeostasis, replacing cells in peripheral lymphoid tissues.
当用绵羊红细胞、细菌脂多糖或牛血清白蛋白对大鼠或小鼠进行免疫时，可在骨髓和脾脏中检测到增殖反应。这种反应与高钙血症期相关。甲状旁腺切除导致持续性低钙血症，可防止血浆钙水平升高。该手术还可防止抗原刺激后骨髓增殖增加，但不会消除脾脏中细胞对抗原的正常增殖反应。甲状旁腺切除不会显著降低抗体产生和抗体形成细胞的数量。这些结果表明，骨髓中存在一群抗原不敏感细胞，抗原刺激后会被激活。据推测，这些事件是由甲状旁腺依赖性高钙血症的发生介导的，该高钙血症非特异性地刺激细胞。这些事件可能是细胞稳态的一部分，用于替代外周淋巴组织中的细胞。
