Ehrensperger M, Petter C, Keuky L
J Embryol Exp Morphol. 1981 Apr;62:109-15.
Recent research on the br/br rabbit is summarized. In all homozygous individuals, limb amputations result from in utero haemorrhages which develop in the extremities and lead to necrosis. An inner-ear abnormality is observed in about 25% of the cases. By studying a large number of gestations and birth, we observed that homozygous crossings result in about 100% amputated animals while crossings between heterozygous and homozygous rabbits result in about 50% of the young being abnormal. Observations of megakaryoblastic cells in 15- and 17-day foetal liver show a predominance of immature cells in 15-day br/br foetuses. This abnormality disappears on day 17. The possible role of megakaryoblastic cells in br/br rabbit amputation is discussed.
本文总结了对br/br兔的近期研究。在所有纯合个体中，肢体截肢是由子宫内出血导致的，这些出血发生在四肢并导致坏死。约25%的病例中观察到内耳异常。通过研究大量的妊娠和出生情况，我们发现纯合交配产生的动物约100%肢体被截肢，而异合子与纯合子兔交配产生的幼崽约50%异常。对15日龄和17日龄胎儿肝脏中的巨核母细胞观察显示，15日龄br/br胎儿中未成熟细胞占优势。这种异常在17日龄时消失。文中讨论了巨核母细胞在br/br兔肢体截肢中可能发挥的作用。
