Metabolism of isoniazid and free hydrazine formation in isolated rat hepatocytes.
作者信息
Hirata M, Aso Y, Hsu K Y, Tabata T, Matsuyama K, Noda A, Iguchi S
出版信息
J Pharmacobiodyn. 1981 Feb;4(2):145-7. doi: 10.1248/bpb1978.4.145.
PMID:7277201
Abstract
Isoniazid (INH) was incubated with isolated rat hepatocytes, and the amounts of acetyl-INH, monoacetylhydrazine, diacetylhydrazine and hydrazine formed were determined by gas chromatography-mass spectrometry (GC-MS). Subsequent analyses of kinetic parameters of metabolic pathways and enzymological study of rat liver homogenate revealed that hydrazine was formed preferentially from INH, catalyzed by soluble hydrolytic enzymes.
摘要
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