Sen D K, Lankaranifard G, Narain N K
J Protozool. 1981 May;28(2):167-70. doi: 10.1111/j.1550-7408.1981.tb02827.x.
The effect of holothurin (a marine biotoxin) on the resistance of mice to trypanosoma musculi was measured by studying changes in the parasite population in vivo. Swiss Webster (SW), Beige (BG), and Black (BL) mice treated with holothurin prior to and simultaneously with infection of trypanosomes had lower parasitemias than controls. Higher levels of parasitemia were observed in mice treated after infection with trypanosomes. The timing of administration of holothurin appeared to be an important factor in the observed effect. The minor variations in the parasitemia seemed to be related to the mouse strain.
通过研究体内寄生虫数量的变化，测定了海参毒素（一种海洋生物毒素）对小鼠抗肌肉锥虫能力的影响。在感染锥虫之前及同时用海参毒素处理的瑞士韦伯斯特（SW）小鼠、米色（BG）小鼠和黑色（BL）小鼠，其虫血症水平低于对照组。在感染锥虫后接受处理的小鼠中观察到了更高水平的虫血症。海参毒素的给药时间似乎是观察到的效果的一个重要因素。虫血症的微小差异似乎与小鼠品系有关。
