红细胞酸性磷酸酶与血红蛋白、触珠蛋白及葡萄糖-6-磷酸脱氢酶（G6PD）表型的表型及定量关系。
Phenotypic and quantitative relationship of red cell acid phosphatase with haemoglobin, haptoglobin, and G6PD phenotypes.
作者信息
Saha N, Patgunarajah N
出版信息
J Med Genet. 1981 Aug;18(4):271-5. doi: 10.1136/jmg.18.4.271.
The phenotypic and quantitative relationship of red cell acid phosphatase with haemoglobin, haptoglobin, and G6PD phenotypes was investigated in three populations in the Sudan and one population in Nilgiris, India. No significant consistent association of red cell acid phosphatase phenotypes was observed with these polymorphisms. However, there was a lack of acid phosphatase AB in G6PD deficient subjects from Nilgiris. The relative quantitative expression of red cell acid phosphatase genes PA, PB, and PC was 1.0, 1.2, and 1.3, respectively. The red cell acid phosphatase activity was higher (15%) in the presence of raised haemoglobin A2 and in sickle cell anaemia (21%). Those with Hp2 had 18% higher level of acid phosphatase than those with Hp1. G6PD deficient subjects had a lower level of acid phosphatase activity (20%) than those with normal G6PD activity.
在苏丹的三个人群和印度尼尔吉里斯的一个人群中，研究了红细胞酸性磷酸酶与血红蛋白、触珠蛋白和葡萄糖-6-磷酸脱氢酶（G6PD）表型之间的表型和定量关系。未观察到红细胞酸性磷酸酶表型与这些多态性之间存在显著的一致性关联。然而，尼尔吉里斯的G6PD缺乏受试者中缺乏酸性磷酸酶AB。红细胞酸性磷酸酶基因PA、PB和PC的相对定量表达分别为1.0、1.2和1.3。在血红蛋白A2升高和镰状细胞贫血的情况下，红细胞酸性磷酸酶活性较高（分别为15%和21%）。拥有Hp2的人酸性磷酸酶水平比拥有Hp1的人高18%。G6PD缺乏受试者的酸性磷酸酶活性水平比G6PD活性正常的受试者低20%。
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