Fitzgerald R H, Kelly P J, Snyder R J, Washington J A
Antimicrob Agents Chemother. 1978 Nov;14(5):723-6. doi: 10.1128/AAC.14.5.723.
The penetrations of methicillin, oxacillin, and cephalothin into cortical bone and synovial tissues were studied 1 h after their intravenous administration in 105 patients having arthroplasty of the hip. Although the lowest serum levels were noted with cephalothin (P < 0.01), more patients receiving cephalothin achieved osseous drug levels inhibitory to staphylococci (P < 0.01). Differences in the penetration of the three agents into synovial tissues were not statistically significant.
对105例行髋关节置换术的患者静脉注射甲氧西林、苯唑西林和头孢噻吩1小时后，研究了它们在皮质骨和滑膜组织中的渗透情况。尽管头孢噻吩的血清水平最低（P<0.01），但接受头孢噻吩治疗的患者中有更多患者的骨药物水平对葡萄球菌具有抑制作用（P<0.01）。三种药物在滑膜组织中的渗透差异无统计学意义。
