• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

氨曲南在滑液和骨中的渗透情况。

Aztreonam penetration into synovial fluid and bone.

作者信息

MacLeod C M, Bartley E A, Galante J O, Friedhoff L T, Dhruv R

出版信息

Antimicrob Agents Chemother. 1986 Apr;29(4):710-2. doi: 10.1128/AAC.29.4.710.

DOI:10.1128/AAC.29.4.710
PMID:3707115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180473/
Abstract

Eighteen patients with uncomplicated degenerative joint disease requiring joint replacement (hip or knee) were given a single 2-g intravenous dose of aztreonam over a 5-min period preoperatively. The mean concentration in synovial fluid of 83.0 +/- 9.2 micrograms/ml averaged 0.99 times the concomitant levels in serum. The mean concentration in cancellous bone of 16.0 +/- 4.3 micrograms/g averaged 0.20 times the concomitant levels in serum.

摘要

18例需要进行关节置换（髋关节或膝关节）的单纯性退行性关节病患者在术前5分钟内静脉注射单剂量2克氨曲南。滑液中的平均浓度为83.0±9.2微克/毫升，平均为同期血清浓度的0.99倍。松质骨中的平均浓度为16.0±4.3微克/克，平均为同期血清浓度的0.20倍。

相似文献

1
Aztreonam penetration into synovial fluid and bone.氨曲南在滑液和骨中的渗透情况。
Antimicrob Agents Chemother. 1986 Apr;29(4):710-2. doi: 10.1128/AAC.29.4.710.
2
Penetration of daptomycin into bone and synovial fluid in joint replacement.达托霉素在关节置换中进入骨组织和滑液的情况。
Antimicrob Agents Chemother. 2014 Jul;58(7):3991-6. doi: 10.1128/AAC.02344-14. Epub 2014 May 5.
3
[Penetration of aztreonam in the synovial fluid].[氨曲南在滑液中的渗透情况]
G Ital Chemioter. 1985 May-Aug;32(2):415-7.
4
The penetration of flucloxacillin into cortical and cancellous bone during arthroplasty of the knee.
Int Orthop. 1982;6(4):243-7. doi: 10.1007/BF00267145.
5
Cephalothin and cefamandole penetration into bone, synovial fluid, and wound drainage fluid.
J Bone Joint Surg Am. 1980 Sep;62(6):981-5.
6
Cefazolin concentrations in bone and synovial fluid.
J Bone Joint Surg Am. 1978 Apr;60(3):359-62.
7
Plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin during total hip replacement.全髋关节置换术中林可霉素的血浆、骨、髋关节囊、滑膜及引流液浓度。
Br J Clin Pharmacol. 1977 Aug;4(4):433-7. doi: 10.1111/j.1365-2125.1977.tb00758.x.
8
High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days.在感染性髋关节假体二期翻修中，从Simplex骨水泥间隔器中洗脱的万古霉素和氨曲南具有高浓度和生物活性：一项对46例患者的研究，平均随访107天。
J Orthop Res. 2006 Aug;24(8):1615-21. doi: 10.1002/jor.20214.
9
Linezolid penetration into osteo-articular tissues.
J Antimicrob Chemother. 2002 Nov;50(5):747-50. doi: 10.1093/jac/dkf207.
10
[Investigation of meropenem levels in the human bone marrow blood, bone, joint fluid and joint tissues].[美罗培南在人骨髓血、骨、关节液及关节组织中的水平研究]
Jpn J Antibiot. 1993 Feb;46(2):159-63.

引用本文的文献

1
Gentamicin in bone cement: A potentially more effective prophylactic measure of infectionin joint arthroplasty.骨水泥中的庆大霉素：关节置换术感染的一种潜在更有效的预防性措施。
Bone Joint Res. 2013 Oct 15;2(10):220-6. doi: 10.1302/2046-3758.210.2000188. Print 2013.
2
Pharmacokinetic optimisation of the treatment of septic arthritis.
Clin Pharmacokinet. 1996 Aug;31(2):156-63. doi: 10.2165/00003088-199631020-00006.

本文引用的文献

1
Cephalothin and cefamandole penetration into bone, synovial fluid, and wound drainage fluid.
J Bone Joint Surg Am. 1980 Sep;62(6):981-5.
2
Pharmacokinetics of cefamandole in osseous tissue.头孢孟多在骨组织中的药代动力学。
Antimicrob Agents Chemother. 1981 May;19(5):851-8. doi: 10.1128/AAC.19.5.851.
3
Cefamandole bone diffusion in patients undergoing total hip replacement.头孢孟多在接受全髋关节置换术患者中的骨扩散情况。
Chemotherapy. 1981;27(3):166-72. doi: 10.1159/000237973.
4
A review of the penetration of cefadroxil into human tissue.头孢羟氨苄在人体组织中的渗透性综述。
J Antimicrob Chemother. 1982 Sep;10 Suppl B:33-8. doi: 10.1093/jac/10.suppl_b.33.
5
Penetration of cefazolin into normal and osteomyelitic canine cortical bone.头孢唑林在正常和骨髓炎犬皮质骨中的渗透情况。
Antimicrob Agents Chemother. 1982 Sep;22(3):461-9. doi: 10.1128/AAC.22.3.461.
6
Penetration of ceforanide and cefamandole into the right atrial appendage, pericardial fluid, sternum, and intercostal muscle of patients undergoing open heart surgery.头孢乙腈和头孢孟多在接受心脏直视手术患者的右心耳、心包液、胸骨和肋间肌中的渗透情况。
Antimicrob Agents Chemother. 1982 Mar;21(3):416-20. doi: 10.1128/AAC.21.3.416.
7
Amoxicillin concentrations in serum, jaw cyst, and jawbone following a single oral administration.单次口服给药后血清、颌骨囊肿和颌骨中的阿莫西林浓度。
J Oral Maxillofac Surg. 1982 May;40(5):287-93. doi: 10.1016/0278-2391(82)90220-8.
8
The pharmacokinetics of penicillin in osteomyelitic canine bone.青霉素在骨髓炎犬骨中的药代动力学。
J Bone Joint Surg Am. 1983 Apr;65(4):526-32.
9
Concentrations of some antibiotics in synovial fluid after oral administration, with special reference to antistaphylococcal activity.口服给药后滑液中某些抗生素的浓度，特别提及抗葡萄球菌活性。
Ann Rheum Dis. 1983 Feb;42(1):67-74. doi: 10.1136/ard.42.1.67.
10
Infectious arthritis complicating systemic lupus erythematosus.感染性关节炎并发系统性红斑狼疮。
Can Med Assoc J. 1980 Apr 5;122(7):791-3.