氨曲南在滑液和骨中的渗透情况。
Aztreonam penetration into synovial fluid and bone.
作者信息
MacLeod C M, Bartley E A, Galante J O, Friedhoff L T, Dhruv R
出版信息
Antimicrob Agents Chemother. 1986 Apr;29(4):710-2. doi: 10.1128/AAC.29.4.710.
Abstract
Eighteen patients with uncomplicated degenerative joint disease requiring joint replacement (hip or knee) were given a single 2-g intravenous dose of aztreonam over a 5-min period preoperatively. The mean concentration in synovial fluid of 83.0 +/- 9.2 micrograms/ml averaged 0.99 times the concomitant levels in serum. The mean concentration in cancellous bone of 16.0 +/- 4.3 micrograms/g averaged 0.20 times the concomitant levels in serum.
摘要
18例需要进行关节置换（髋关节或膝关节）的单纯性退行性关节病患者在术前5分钟内静脉注射单剂量2克氨曲南。滑液中的平均浓度为83.0±9.2微克/毫升，平均为同期血清浓度的0.99倍。松质骨中的平均浓度为16.0±4.3微克/克，平均为同期血清浓度的0.20倍。
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