无胸腺裸鼠体内人类黑色素瘤的肿瘤生长及化疗反应评估
Assessment of tumour growth and of response to chemotherapy of human melanomas in athymic, nude mice.
作者信息
Fodstad O, Aass N, Pihl A
出版信息
Br J Cancer Suppl. 1980 Apr;4:146-9.
Abstract
The growth of 6 different human melanomas xenografted into athymic mice was followed by measuring 2 vertical diameters twice weekly. The growth rate of the xenografts was expressed as the tumour doubling time, measured in the volume range 30-60 mm3. None of the xenografts increased their growth rate with increasing number of passages. The tumour lines, which were histologically very similar, showed individual, characteristic growth rates differing by a factor of 3. Evidence was obtained that resistance to cytostatic drugs in the patients is retained in the xenograft. Procedures for evaluating response to chemotherapy are discussed.
摘要
将6种不同的人类黑色素瘤移植到无胸腺小鼠体内，通过每周两次测量两个垂直直径来跟踪其生长情况。异种移植物的生长速率用肿瘤倍增时间表示，在30 - 60立方毫米的体积范围内进行测量。没有一种异种移植物随着传代次数的增加而提高其生长速率。这些组织学上非常相似的肿瘤系显示出各自独特的生长速率，相差3倍。有证据表明，患者对细胞抑制药物的耐药性在异种移植物中得以保留。文中讨论了评估化疗反应的程序。
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