Körst H A, Brandes J W, Littmann K P
Med Klin. 1981 Jun 5;76(12):349-50.
In a 68 years old female patient with premature ventricular contractions who was treated with phenprocoumon (Marcumar) because of pulmonary infarction, propafenon (Rytmonorm)--a new anti-arrhythmic drug--lead to an increased effect of coumarin. Inspite of pausing with coumarin for eight days the low Quick rates (less than 15%) did not increase until propafenon was stopped. Afterwards the coumarin treatment was continued with 1,5 to 3 mg a day. In case of a combined treatment with propafenon and coumarin Quick rates should be controlled frequently.
一名68岁患有室性早搏的女性患者因肺梗死接受苯丙香豆素（Marcumar）治疗，新型抗心律失常药物普罗帕酮（Rytmonorm）导致香豆素的药效增强。尽管停用香豆素八天，但低凝血酶原时间率（低于15%）直到停用普罗帕酮才升高。之后继续使用香豆素治疗，每日剂量为1.5至3毫克。在普罗帕酮与香豆素联合治疗的情况下，应频繁监测凝血酶原时间率。
