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[Profound granulocytopenia in a patient treated with propafenon ].

作者信息

Mayrhofer E F, Davogg S, Feilhauer G D, Pilecky I, Seisenbacher H, Vockner H

出版信息

Wien Med Wochenschr. 1982 Jun 15;132(11):273-5.

PMID:7123969
Abstract

A case report concerning a 75 year old female patient whose treatment of multifocal ventricular extrasystoles and a ventricular tachycardia after an acute myocardial infarction consisted of multiple drugs, one of them being the antiarrhythmic substance Propafenon, is given. The patient developed a profound, but reversible, granulocytopenia, which disappeared nine days after discontinuing of most of the drugs. With the exemption of Propafenon all of the drugs were reinstituted after the remission: The not anymore needed ones only for a few days, all others until now, without ill effect. The patient is doing fairly well one year after this episode.

摘要

相似文献

1
[Profound granulocytopenia in a patient treated with propafenon ].
Wien Med Wochenschr. 1982 Jun 15;132(11):273-5.
2
[Beware: propafenon potentiates the effect of oral anticoagulants].注意:普罗帕酮会增强口服抗凝剂的作用。
Med Klin. 1981 Jun 5;76(12):349-50.
3
Propafenone for the treatment of severe ventricular arrhythmias.普罗帕酮治疗严重室性心律失常。
Can Med Assoc J. 1984 Sep 15;131(6):601-3.
4
[Disturbances of potency and spermiogenesis due to propafenon (author's transl)].普罗帕酮所致的性功能和精子生成障碍(作者译)
Dtsch Med Wochenschr. 1980 Aug 22;105(34):1187-9. doi: 10.1055/s-2008-1070837.
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[Clinical study of a new anti-arrhythmic drug: propafenon. Short and long-term results].
Arch Inst Cardiol Mex. 1981 Jul-Aug;51(4):371-6.
6
[Comparative study on the efficacy of disopyramide and propafenone in the prevention of the recurrence of ventricular tachycardia].
G Ital Cardiol. 1984 May;14(5):357-9.
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[Propafenon, a new anti-arrhythmic drug (author's transl)].
Dtsch Med Wochenschr. 1976 Sep 3;101(36):1318-22. doi: 10.1055/s-0028-1104264.
8
Fatal ventricular tachycardia in association with propafenone, a new class IC antiarrhythmic agent.与新型IC类抗心律失常药物普罗帕酮相关的致命性室性心动过速。
Postgrad Med J. 1984 Feb;60(700):155-6. doi: 10.1136/pgmj.60.700.155.
9
Clinical evaluation of new antiarrhythmic agents: experiences with propafenone.
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引用本文的文献

1
Propafenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias.普罗帕酮。对其药效学和药代动力学特性以及在心律失常治疗中的治疗用途的综述。
Drugs. 1987 Dec;34(6):617-47. doi: 10.2165/00003495-198734060-00001.
2
Drug-induced agranulocytosis.药物性粒细胞缺乏症
Med Toxicol Adverse Drug Exp. 1988 Nov-Dec;3(6):449-62. doi: 10.1007/BF03259896.
3
Clinical pharmacokinetics of propafenone.
Clin Pharmacokinet. 1991 Jul;21(1):1-10. doi: 10.2165/00003088-199121010-00001.