Ludwig A M, Bendfeldt F, Wikler A, Cain R B
Arch Gen Psychiatry. 1978 Mar;35(3):370-3. doi: 10.1001/archpsyc.1978.01770270120012.
This study evaluates the ability of alcoholics to regulate their blood alcohol levels (BAL) within a designated range by relying primarily on interoceptive cues. Forty male alcoholics and 20 control subjects were exposed to an initial training session in which they received sufficient ethanol to maintain them within a designated BAL range over a 2 1/2-hour period. They were then exposed to two experimental sessions, one providing "overfeedback" and one "underfeedback." During each session, subjects had ten drinking decisions to make with respect to regulation of their BAL. The results indicated that alcoholics displayed greater "loss-of-control" than control subjects. This finding supported the hypothesis that alcoholics may possess a neurophysiologic feedback dysfunction that contributes to their relative inability to regulate ethanol intake.
本研究评估酗酒者主要依靠内感受性线索将血液酒精浓度（BAL）调节至指定范围内的能力。40名男性酗酒者和20名对照受试者接受了初始训练，在训练中他们摄入了足够的乙醇，使其在2个半小时内维持在指定的BAL范围内。然后他们接受了两个实验环节，一个提供“过度反馈”，另一个提供“反馈不足”。在每个环节中，受试者就其BAL的调节要做出10次饮酒决定。结果表明，酗酒者比对照受试者表现出更大的“失控”。这一发现支持了以下假设：酗酒者可能存在神经生理反馈功能障碍，这导致他们相对无法调节乙醇摄入量。
